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Avanir Pharmaceuticals is conducting a survey on a relatively common but under-recognized neurologic condition called pseudobulbar affect (PBA). We are seeking your opinion based on your experience with this condition.

Pseudobulbar affect (PBA) is a neurologic condition characterized by frequent, uncontrollable outbursts of crying or laughing. These involuntary episodes may appear suddenly, may be exaggerated, or may not match what the person is feeling inside. PBA is associated with underlying neurologic conditions or injuries including: Alzheimer’s disease or other dementias, stroke, traumatic brain injury (TBI), multiple sclerosis (MS), Parkinson’s disease and Lou Gehrig’s disease (ALS). PBA is sometimes referred to by other terms, such as emotional lability, pathological crying and laughing, or emotional incontinence. Thank you for taking the time to participate in this survey today.
 
 
 
1. In which country do you primarily practice medicine?
   
 
 
2. On average, how many patients do you see each week with the following neurologic conditions:
Number of patients
Amyotrophic lateral sclerosis (ALS)
Multiple sclerosis (MS)
Dementia
Parkinson’s disease (PD)
Stroke
Traumatic brain injury (TBI)
 
 
 
On average, how many patients do you see each week with pseudobulbar affect (PBA)?
 
 
 
4. How significant do you think the burden associated with pseudobulbar affect (PBA) is? Consider the physical, emotional, and financial burden.
(Select one only)
 
Not significant at all
 
Mildly significant
 
Moderately significant
 
Very significant
 
Extremely significant
 
 
5. Approximately what percentage of your patients with pseudobulbar affect (PBA) were diagnosed by you, and what percentage of them came to you with an existing diagnosis of PBA?
Percentage (%)
Diagnosed by you
Came to you with a diagnosis
 
 
 
6. Which method, instrument or criterion do you use to diagnose pseudobulbar affect (PBA)?
(Select as many that apply)
 
Guidelines
 
Pathological Laughter and Crying Scale(PLACS)
 
Center for Neurologic Study‒Lability Scale(CNS-LS)
 
Clinical evaluation
 
Other instrument/scale or method
 

 
 
 
7. How high is awareness of pseudobulbar affect (PBA) among your colleagues?
(Select one only)
 
Very low
 
Low
 
Medium
 
High
 
Very high
 
 
 
8. On a scale of 1-7, how important do you think it is to treat the symptoms of pseudobulbar affect (PBA)? (1 = not at all important; 7 = critically important)
(Select one only)
 
1 (not at all important)
 
2
 
3
 
4
 
5
 
6
 
7 (critically important)
 
 
9. Please distribute your current patients with pseudobulbar affect (PBA) across the following three categories. The % must add to 100%.

Percentage (%)
% of patients currently on medication for their PBA symptoms
% of patients who were previously on medication for their symptoms but are no longer receiving treatment
% of patients who are not on medication for their PBA symptoms
 
 
 
10. What medications do you typically use to treat pseudobulbar affect (PBA) in your patients?
   
 
 
 
11. On a scale of 1-7, how high is the level of unmet medical need in treating pseudobulbar affect (PBA)? (1= very low; 7=very high)
(Select one only)
 
1 (very low)
 
2
 
3
 
4
 
5
 
6
 
7 (very high)
 
 
 
12. What would you like to see in a new therapy to be convinced to utilize it for treating pseudobulbar affect (PBA)?
(Select as many that apply)
 
Clinical trial data
 
Specific endpoints
 
Specific indication for PBA on the product label
 
Physician organization support
 
Peer recommendation
 
Guidelines
 
Other(s)
 

 
Pseudobulbar affect (PBA) is a neurologic condition characterized by involuntary episodes of crying and/or laughing that are mood incongruent or exaggerated relative to the external environment. PBA is also known as emotional lability, pathological crying and laughing, or emotional incontinence. PBA occurs secondary to certain neurologic diseases or injury to the brain.